Comments(1)

Reactive Oxygen Species, Oxidative - Redox Stress Occur Upstream from Inflammation

Melvin Hayden   (26 February 2004)  Dept. of Family and Community Medicine Universtiy of Missouri

Dr. Altman,

Congratulations on your fine review aricle. I found it to be very informative and extrememly well written!

I think it is exciting that Redox Stress occurs upstream from the inflammatory process and is further induced by the inflammatory process creating a pernicious cycle of damage and dysfunction to the endothelial cell!

I work with Dr. Tyagi of reference 145 and we are quite interested in diabetes and homocysteine.

We think it is also exciting that the induced vasa vasorum acts as a custom delivery system to deliver the accelerated substrates to continue the ongoing inflammatory process within the atherosclerotic proinflammatory and prothrombotic vulnerable plaques. We also feel that diabetes is a vascular disease even before the diagnosis of overt type 2 diabetes.

Cardiovasular Diabetology: Vol 3:1 Feb 2004 Vasa vasorum....

Is type 2 diaabetes a vascular disease Feb 2003

INtimal redox stress.... Sept 2002

We are interested in your thoughts regarding von Willebrand factor in the setting of accelerated atherosclerosis --> atheroscleropathy,metabolic syndrome,and overt type 2 diabetes mellitus in atherothrombosis ?

Again, thank you for a great paper in this exciting field of study!

Sincerely,

M.R. (Pete) Hayden, M.D.

Adjunct Assistant Professor

Department of Family and Community Medicine

University of Missouri

School of Medicine

Competing interests

NONE

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