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Open Access Highly Accessed Review

Heparin-induced thrombocytopenia: an update

Massimo Franchini

Author Affiliations

Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy

Thrombosis Journal 2005, 3:14  doi:10.1186/1477-9560-3-14

Published: 4 October 2005

Abstract

Heparin-induced thrombocytopenia (HIT) is the most important and most frequent drug-induced, immune-mediated type of thrombocytopenia. It is associated with significant morbidity and mortality if unrecognized. In this review, we briefly discuss the main features of heparin-induced thrombocytopenia, particularly analyzing the most recent advances in the pathophysiology, diagnosis and treatment of this syndrome.

Keywords:
Platelets; heparin; thrombosis