Table 1

Activating effect of agonists on Lag Time.
Assay System N-PRP plus
 Lag Time (minutes) mean ± SD


B
 C
 D
 E
 F
 G
 H

Saline
 rFVIIa 5 μg/mL
 p value B vs C
 rFVIIa 2.6 μg/mL
 P value B vs E
 rFVIIa 0.5 μg/mL
 p value B vs G
1. Saline
 17.1 ± 5.1
 7.9 ± 2.1
 <0.001
 8.2 ± 2.4
 <0.001
 9.0 ± 1.9
 <0.001
2. ADP 2 μM
 11.5 ± 3.0
 7.2 ± 2.0
 <0.001
 7.6 ± 1.6
 <0.001
 8.1 ± 2.0
 <0.001
3. Col 0.5 μg/mL
 11.9 ± 3.1
 7.0 ± 2.8
 <0.001
 7.9 ± 2.8
 <0.001
 8.4 ± 2.9
 <0.001
4. AA 0.625 mmol/L
 8.4 ± 2.0
 5.9 ± 1.2
 <0.05
 6.2 ± 1.3
 <0.05
 6.8 ± 1.3
 <0.05
5. AA 0.125 mmol/L
 9.5 ± 2.7
 6.5 ± 1.5
 <0.05
 7.0 ± 1.8
 <0.05
 7.3 ± 1.7
 <0.05

Parameters of TG in PRP from 29 normal volunteers. Effect of ADP, collagen (Col); sodium arachidonate (AA) and rFVIIa at different concentrations.

Column B:1 vs 2 to 5 p < 0.01 Column C: 1 vs 4 and 5 p < 0.01; Column E. 1 vs 4 and 5 p < 0.005 for both; Column G. 1 vs 4 and 5 p < 0.01 for both.

Altman et al. Thrombosis Journal 2006 4:5   doi:10.1186/1477-9560-4-5