Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications

doi:10.1186/1477-9560-5-14

Thrombosis Journal

Volume 5

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Franchini M
Capra F
Targher G
Montagnana M
Lippi G

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Capra F
Targher G
Montagnana M
Lippi G
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Review

Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications

Massimo Franchini¹ , Franco Capra² , Giovanni Targher³ , Martina Montagnana⁴ and Giuseppe Lippi⁴

¹Servizio di Immunoematologia e Trasfusione – Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy

²Medicina Interna C, Dipartimento di Scienze Biomediche e Chirurgiche, Università di Verona, Verona, Italy

³Sezione di Endocrinologia e Malattie del Metabolismo, Dipartimento di Scienze Biomediche e Chirurgiche, Università di Verona, Verona, Italy

⁴Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Università di Verona, Verona, Italy

author email corresponding author email

Thrombosis Journal 2007, 5:14doi:10.1186/1477-9560-5-14


Published:	25 September 2007

Abstract

Although a number of studies have demonstrated the influence of ABO blood group on plasma levels of von Willebrand factor (VWF), the nature of this association and its clinical importance is still largely unknown.

In this review, the most recent advances in our understanding of the mechanisms by which ABO blood group determines plasma VWF levels and their clinical impact will be discussed.