Table 2

Proinflammatory SNPs stratified by race and case/control status demonstrating allelic variants, genotype call rate, minor allele frequencies and p-values for age-adjusted additive model and risk factor adjusted additive model.
Gene
 SNP rs number, location and function
 Alleles*
 Call Rate (%)
 African-Americans
 Caucasians




Cases
 Controls
 p-value
 Cases
 Controls
 p-value




Minor Allele Frequency/N
 Minor Allele Frequency/N
 Age-adjusted
 Risk factor adjusted**
 Minor Allele Frequency/N
 Minor Allele Frequency/N
 Age-adjusted
 Risk factor adjusted**
CD14ψ
 rs2569190, 5' promotor
 C/T
 99%
 0.38/77
 0.42/62
 0.57
 0.66
 0.49/65
 0.40/75
 0.13
 0.30
IL1A
 rs17561, exon 4 nonsynonymous
 G/T
 98%
 0.18/102
 0.18/90
 0.83
 0.73
 0.27/93
 0.31/94
 0.32
 0.80
IL1R1
 rs3917318, intron 10
 A/G
 91%
 0.33/97
 0.29/88
 0.44
 0.23
 0.33/92
 0.36/92
 0.53
 0.24
ILIB
 rs3917365, 3' near gene
 C/T
 81%
 0.21/97
 0.17/83
 0.34
 0.36
 0.08/86
 0.08/89
 0.85
 0.87
IL6
 rs1800797, 5' near gene
 A/G
 91%
 0.06/99
 0.10/88
 0.19
 0.18
 0.42/93
 0.43/91
 0.89
 0.87

rs2069830, exon 2 nonsynonymous
 C/T
 91%
 0.07/100
 0.09/87
 0.32
 0.31
 0.01/90
 0.03/93
 0.30
 0.35

rs2069832, intron 2
 C/T
 89%
 0.05/97
 0.12/86
 0.049
 0.05
 0.45/92
 0.45/91
 0.97
 0.85
MMP3
 rs679620, exon 2 nonsynonymous
 C/T
 89%
 0.35/103
 0.35/88
 0.95
 0.72
 0.45/90
 0.47/96
 0.85
 1.0

ψCD14 SNP rs2569190 was genotyped in a smaller case-control sample (N = 315).

* Minor allele in African-Americans (bolded in column 3 above).

** Risk factor adjusted – Additive model adjusted for age, hypertension, diabetes, oral contraceptive use, and angina-MI.

Cole et al. Thrombosis Journal 2008 6:11   doi:10.1186/1477-9560-6-11