Figure 2.

ADP (5 μM) -stimulated platelet aggregation after pretreatment with MRS2500 (1 μM) ex vivo [a], after pretreatment with clopidogrel (600 mg) po and MRS2500 ex vivo [b], and after pretreatment with clopidogrel (600 mg) po and AZD6140 (10 μM) ex vivo [c]. n = 8. Filled symbols represents normothermia (37°), open symbols represents hypothermia (33°), n.s. = not significant, * = P < 0.05, *** = P < 0.001.