The activity of pregnancy-associated plasma protein A (PAPP-A) as expressed by immunohistochemistry in atherothrombotic plaques obtained by aspiration thrombectomy in patients presenting with a ST-elevation myocardial infarction: a brief communication

doi:10.1186/1477-9560-8-1

Thrombosis Journal

Volume 8

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Brügger-Andersen T
Bostad L
Sandnes DA
Larsen AI
Bonarjee VV
Barvik S
Melberg T
Nilsen DW

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Brügger-Andersen T
Bostad L
Sandnes DA
Larsen AI
Bonarjee VV
Barvik S
Melberg T
Nilsen DW
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Original clinical investigation

The activity of pregnancy-associated plasma protein A (PAPP-A) as expressed by immunohistochemistry in atherothrombotic plaques obtained by aspiration thrombectomy in patients presenting with a ST-elevation myocardial infarction: a brief communication

Trygve Brügger-Andersen¹^,2 , Leif Bostad⁴^,5 , Dagny Ann Sandnes³ , Alf Inge Larsen¹^,2 , Vernon VS Bonarjee¹^,2 , Ståle Barvik¹^,2 , Tor Melberg¹^,2 and Dennis WT Nilsen¹^,2

¹Institute of Medicine, University of Bergen, 5021 Bergen, Norway

²Department of Medicine, Stavanger University Hospital, 4068 Stavanger, Norway

³Institute of Surgery, University of Bergen, 5021 Bergen, Norway

⁴Department of Pathology, Haukeland University Hospital, Bergen, Norway

⁵Section for Pathology, The Gade Institute, University of Bergen, 5021 Bergen, Norway

author email corresponding author email

Thrombosis Journal 2010, 8:1doi:10.1186/1477-9560-8-1


Published:	27 January 2010

Abstract

Background

The expression of pregnancy-associated plasma protein A (PAPP-A) was identified by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with ST-segment elevation myocardial infarction (STEMI).

Methods

The atherothrombotic samples were collected from a consecutive cohort consisting of 20 individuals admitted with STEMI to Stavanger University Hospital, Norway, from 2005-2006, presenting angiographically with an acute thrombotic occlusion of a coronary artery characterized by TIMI flow 0. The atherothrombotic plaques were obtained by aspiration thrombectomy during percutaneous coronary intervention within 12 hours from the onset of symptoms and prepared for IHC analysis.

Results

In the IHC analysis staining for PAPP-A occurred in the extracellular matrix of the plaques and no evidence of staining for PAPP-A was found in the thrombi.

Conclusion

Our results indicate that in vivo PAPP-A is strongly expressed in atherothrombotic plaques harvested from patients admitted with STEMI, as documented by IHC.

Trial registration

biobankregisteret@fhi.no1846