Postpartal recurrent non-ST elevation myocardial infarction in essential thrombocythaemia: case report and review of the literature
1 Department of Nephrology/Hypertension, University of Bern, Berne, Switzerland
2 Department of Nephrology, University of Thessaly, Larissa, Greece
3 Women's Hospital, University of Bern, Berne, Switzerland
Thrombosis Journal 2010, 8:12 doi:10.1186/1477-9560-8-12Published: 17 June 2010
Normal pregnancy corresponds to a procoagulant state. Acute myocardial infarction during pregnancy is rare, yet considering the low non-pregnant risk score of childbearing women it is still surprisingly frequent. We report a case of postpartum recurrent non-ST elevation myocardial infarction in a 40-year-old caucasian woman with essential thrombocythaemia in the presence of a positive JAK-2 mutation and an elevated anti-cardiolipin IgM antibody titer. In the majority of cases of myocardial infarction in pregnancy or in the peripartal period, atherosclerosis, a thrombus or coronary artery dissection is observed. The combination of essential thrombocythaemia and elevated anti-cardiolipin IgM antibody titer in the presence of several cardiovascular risk factors seems to be causative in our case. In conclusion, with the continuing trend of childbearing at older ages, rare or unlikely conditions leading to severe events such as myocardial infarction must be considered in pregnant women.