[Anticardiolipin antibodies, cerebral ischemia and adrenal hemorrhage in a newborn infant]
[Article in French]
Teyssier G, Gautheron V, Absi L, Galambrun C, Ravni C, Lepetit JC.
Service de réanimation pédiatrique, hôpital Nord, Saint-Etienne, France.
BACKGROUND--Anticardiolipin antibodies, usually associated with vascular thrombosis in systemic lupus erythematosus, have been recently found associated with strokes in childhood, and acute adrenal hemorrhage in the adult. CASE REPORT--A 3 day-old fullterm newborn suffering from cerebrovascular ischemia and bilateral massive hemorrhage was found to have anticardiolipin antibodies detected during the neonatal period and 7 months later. There was no evidence of pathology in the mother or perinatal asphyxia. However, anticardiolipin antibodies were present in the mother 5 and 15 weeks after delivery. CONCLUSION--Association of anticardiolipin antibodies and vascular thrombosis has never been reported in the neonate. Persistence of such antibodies favor the hypothesis that they are not transmitted by the mother; they could represent an early manifestation of primary antiphospholipid syndrome.
Publication Types:
PMID: 8547978 [PubMed - indexed for MEDLINE]